Gamma-aminobutyric acid signaling pathway

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LUM, DCN, and C1R, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid signaling pathway activity versus LUM in TGCT (Pearson r = -0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	LUM →	-2.328	-0.044	<.001	<.001	3	15
TGCT	DCN →	-2.362	-0.036	<.001	<.001	3	15
SCLC	C1R →	-1.324	-0.129	.001	.001	2	15
THYM	MN1 →	-2.225	-0.044	<.001	<.001	3	14
PAAD	KIF1A →	-1.340	-0.053	<.001	<.001	3	14
TGCT	MFAP4 →	-1.615	-0.030	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007214 vs LUM — TGCT

Explore this scatter interactively →