Gamma-aminobutyric acid signaling pathway

Across TCGA patient cohorts, RNA activity of the Gamma-aminobutyric acid signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are L3MBTL2_S689, VPS37B, and HID1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid signaling pathway activity versus L3MBTL2_S689 in OV (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	L3MBTL2_S689 →	-0.671	-0.061	.002	<.001	3	5
UCEC	VPS37B →	+0.225	+0.060	<.001	.007	3	5
UCEC	HID1 →	+0.385	+0.083	<.001	<.001	3	5
GBM	PLCL2 →	+0.363	+0.098	<.001	<.001	3	5
GBM	WBP2 →	+0.211	+0.071	.004	.003	3	4
COAD	PRPS1 →	+0.237	+0.044	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007214 vs L3MBTL2_S689 — OV

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