Gamma-aminobutyric acid signaling pathway

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAYSD1, FAM186B, and SPG7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAYSD1 grouped by Gamma-aminobutyric acid signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SAYSD1 →	-0.761	-0.662	<.001	<.001	3	5
OVARY	FAM186B →	-0.325	-0.867	.008	.007	3	4
OVARY	SPG7 →	-0.595	-0.816	.002	.009	3	4
CNS	CALR →	-0.898	-0.711	.004	.003	3	4
BREAST	ABCB8 →	-0.762	-0.714	.006	.003	3	4
LIVER	PRXL2B →	-1.418	-1.639	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAYSD1 by Gamma-aminobutyric acid signaling pathway activity — BREAST

Explore this box plot interactively →