Gamma-aminobutyric acid signaling pathway

Across TCGA cell cohorts, RNA activity of the Gamma-aminobutyric acid signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI2, FOSL1, and WDR44, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gamma-aminobutyric acid signaling pathway activity versus GNAI2 in SOFT_TISSUE (Pearson r = 0.74).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GNAI2 →	+1.905	+0.349	.009	.006	3	6
SOFT_TISSUE	FOSL1 →	+4.570	+0.250	.005	.009	3	6
BLOOD_Lymphoma	WDR44 →	+1.136	+0.272	.001	.007	3	6
PANCREAS	BDNF →	+2.300	+0.217	<.001	<.001	3	6
LUNG_NSCLC_LUAD	CATSPER1 →	+1.229	+0.191	.004	.001	3	6
BLOOD_Lymphoma	ACTN4 →	+1.123	+0.268	.009	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007214 vs GNAI2 — SOFT_TISSUE

Explore this scatter interactively →