G protein-coupled acetylcholine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITPR1, NFATC2, and NASP_S480, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled acetylcholine receptor signaling pathway activity versus ITPR1 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ITPR1 →	+0.301	+0.058	.007	.003	3	5
GBM	NFATC2 →	+0.364	+0.053	<.001	<.001	3	5
GBM	NASP_S480 →	-1.076	-0.059	<.001	.004	3	5
GBM	OBI1 →	-0.394	-0.074	.001	<.001	3	5
GBM	ARHGAP25 →	+0.550	+0.067	<.001	<.001	3	5
GBM	PLEKHO2 →	+0.255	+0.048	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007213 vs ITPR1 — GBM

Explore this scatter interactively →