G protein-coupled acetylcholine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are THEMIS2, PRKCB, and SIGLEC10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, G protein-coupled acetylcholine receptor signaling pathway activity versus THEMIS2 in HNSC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	THEMIS2 →	+0.881	+0.184	.007	<.001	3	6
LSCC	PRKCB →	+0.884	+0.221	<.001	.001	3	6
LSCC	SIGLEC10 →	+0.692	+0.187	<.001	.002	3	6
GBM	VSIR →	+0.759	+0.973	.001	.004	3	5
LSCC	CSF3R →	+0.858	+0.183	.001	.006	3	5
HNSC	LILRB2 →	+0.690	+0.142	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007213 vs THEMIS2 — HNSC

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