G protein-coupled acetylcholine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE3B, ENY2, and PELI1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE3B grouped by G protein-coupled acetylcholine receptor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UBE3B →	+0.553	+1.196	.002	<.001	3	5
LUNG_NSCLC_LUSC	ENY2 →	-1.003	-1.133	.003	.007	3	4
LUNG_NSCLC_LUSC	PELI1 →	-1.965	-1.490	<.001	<.001	3	4
LUNG_SCLC	MRPL54 →	-0.874	-1.350	.003	.004	3	4
BLOOD_Myeloma	DBP →	-0.989	-1.392	.004	.001	3	3
OVARY	PHF20L1 →	-0.793	-1.046	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE3B by G protein-coupled acetylcholine receptor signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →