Dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Dopamine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DDX27, PRKDC, and UBR5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine receptor signaling pathway activity versus DDX27 in LSCC (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DDX27 →	-0.381	-0.039	.003	.002	3	7
GBM	PRKDC →	-0.330	-0.097	<.001	<.001	3	7
UCEC	UBR5 →	-0.182	-0.048	<.001	.006	3	7
GBM	SF3B3 →	-0.262	-0.077	<.001	<.001	3	6
GBM	VIRMA →	-0.200	-0.067	<.001	<.001	3	6
LSCC	REXO4 →	-0.429	-0.042	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007212 vs DDX27 — LSCC

Explore this scatter interactively →