Dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFA, MAST1, and HPS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VEGFA grouped by Dopamine receptor signaling pathway-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	VEGFA →	-1.988	-1.162	.006	.002	3	4
BLOOD_Leukemia	MAST1 →	-0.958	-0.862	.006	.004	3	3
BLOOD_Leukemia	HPS1 →	-0.803	-1.046	.003	.005	3	3
BLOOD_Leukemia	CTH →	-2.103	-1.242	<.001	<.001	3	3
BLOOD_Leukemia	LCA5L →	-0.438	-1.239	.006	<.001	3	3
LUNG_NSCLC_LUSC	P2RY4 →	+0.140	+1.134	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VEGFA by Dopamine receptor signaling pathway activity — LUNG_SCLC

Explore this box plot interactively →