Dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Dopamine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GNAS, GNB1, and GNA11, each associated with the pathway in up to 19 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Dopamine receptor signaling pathway activity versus GNAS in LIVER (Pearson r = 0.90).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GNAS →	+1.770	+0.438	.001	.001	3	19
URINARY_TRACT	GNB1 →	+1.325	+0.437	.007	.001	3	16
SOFT_TISSUE	GNA11 →	+1.460	+0.397	<.001	<.001	3	16
BONE	GNB2 →	+1.229	+0.287	<.001	.005	3	16
LIVER	RRAS →	+1.741	+0.301	.002	.008	3	10
BONE	CYB5R3 →	+1.574	+0.322	<.001	.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007212 vs GNAS — LIVER

Explore this scatter interactively →