Serotonin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Serotonin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCCC1-AS1, LAT, and GTF2IP23, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin receptor signaling pathway activity versus MCCC1-AS1 in LUSC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MCCC1-AS1 →	-0.602	-0.030	<.001	<.001	2	20
THYM	LAT →	-1.041	-0.039	<.001	<.001	1	19
TGCT	GTF2IP23 →	-1.225	-0.042	<.001	<.001	3	17
UVM	THUMPD3-AS1 →	-0.598	-0.052	<.001	<.001	3	17
GBM	CENATAC →	-0.699	-0.040	<.001	<.001	3	17
GBM	RNA5SP383 →	-0.936	-0.030	<.001	.003	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007210 vs MCCC1-AS1 — LUSC

Explore this scatter interactively →