Serotonin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Serotonin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSPG4, SEC11C, and SERPINB5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin receptor signaling pathway activity versus CSPG4 in PDAC (Pearson r = -0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CSPG4 →	+0.342	+0.029	.006	.001	3	5
LSCC	SEC11C →	-0.915	-0.046	<.001	<.001	3	4
LSCC	SERPINB5 →	+0.963	+0.040	<.001	.001	3	4
LSCC	RALB →	+0.465	+0.040	<.001	<.001	3	4
CCRCC	RPF1 →	-0.214	-0.043	.004	.003	3	4
CCRCC	CCDC47 →	-0.175	-0.046	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007210 vs CSPG4 — PDAC

Explore this scatter interactively →