Serotonin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Serotonin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HRH1, ISX, and GRAMD2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin receptor signaling pathway activity versus HRH1 in LSCC (Pearson r = -0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HRH1 →	+0.954	+0.356	<.001	<.001	3	4
LSCC	ISX →	+0.227	+0.279	.004	<.001	3	4
OV	GRAMD2A →	+1.123	+0.197	<.001	.005	3	3
UCEC	LMO2 →	+0.718	+0.428	.004	<.001	3	3
COAD	GGTLC2 →	+0.034	+0.218	.003	.001	3	3
LUAD	RHOH →	-0.567	-0.145	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007210 vs HRH1 — LSCC

Explore this scatter interactively →