Serotonin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Serotonin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HRH1_S233, HRH1_S230, and CHRM1_S322, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Serotonin receptor signaling pathway activity versus HRH1_S233 in UCEC (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HRH1_S233 →	+1.053	+0.457	<.001	<.001	3	7
GBM	HRH1_S230 →	+0.893	+0.458	<.001	<.001	2	5
BRCA	CHRM1_S322 →	+2.161	+0.356	<.001	<.001	3	3
HNSC	DENND4C_S1337 →	+0.660	+0.210	<.001	<.001	3	3
HNSC	IFITM2 →	+0.616	+0.256	.004	<.001	3	3
GBM	CLASRP_S547 →	-0.264	-0.504	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007210 vs HRH1_S233 — UCEC

Explore this scatter interactively →