Serotonin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Serotonin receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBLL1, CAMK2D, and GNB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CBLL1 grouped by Serotonin receptor signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CBLL1 →	+0.193	+0.183	.003	.006	3	5
BREAST	CAMK2D →	-0.136	-0.280	<.001	<.001	3	5
BREAST	GNB1 →	-0.119	-0.190	.003	.001	3	4
BREAST	SRSF7 →	+0.462	+0.204	<.001	.007	3	4
BREAST	EIF4H →	+0.302	+0.237	.002	<.001	3	4
LARGE_INTESTINE	GIMAP7 →	+0.170	+0.139	.004	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CBLL1 by Serotonin receptor signaling pathway activity — BREAST

Explore this box plot interactively →