Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGAL, ANKRD44, and WAS, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway activity versus ITGAL in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITGAL →	+0.587	+0.098	.001	.001	3	9
HNSC	ANKRD44 →	+0.452	+0.099	<.001	<.001	3	9
UCEC	WAS →	+0.728	+0.114	<.001	<.001	3	8
LUAD	ZAP70 →	+0.419	+0.092	<.001	<.001	3	8
GBM	FYB1 →	+0.547	+0.090	<.001	<.001	3	8
HNSC	IL16 →	+0.593	+0.076	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007207 vs ITGAL — UCEC

Explore this scatter interactively →