Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCB, RASGRP2, and SLC8A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway activity versus PRKCB in BRCA (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKCB →	+0.873	+0.689	<.001	<.001	3	5
HNSC	RASGRP2 →	+0.543	+0.195	<.001	.001	3	5
BRCA	SLC8A1 →	+0.207	+0.520	.006	<.001	3	5
OV	LILRB3 →	+0.744	+0.214	<.001	.006	3	4
CCRCC	XCR1 →	+0.484	+0.710	.001	.002	3	4
HNSC	CD28 →	+0.840	+0.225	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007207 vs PRKCB — BRCA

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