Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHG2, PTGS1, and BAZ1B, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway activity versus PLEKHG2 in BLOOD_Leukemia (Pearson r = -0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLEKHG2 →	-0.828	-1.663	.003	.001	3	1
BLOOD_Leukemia	PTGS1 →	+3.436	+1.663	.003	.001	3	1
BLOOD_Leukemia	BAZ1B →	-0.943	-1.925	.003	<.001	3	1
BLOOD_Leukemia	THOC3 →	-1.336	-1.834	.002	.001	3	1
BLOOD_Leukemia	HHAT →	-1.220	-1.663	.007	.001	3	1
BLOOD_Leukemia	FOXC1 →	+1.694	+1.663	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007207 vs PLEKHG2 — BLOOD_Leukemia

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