Positive regulation of cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC150, TNRC6A, and EDRF1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytosolic calcium ion concentration activity versus CCDC150 in URINARY_TRACT (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CCDC150 →	-1.463	-0.105	<.001	<.001	3	14
BLOOD_Lymphoma	TNRC6A →	-1.114	-0.081	<.001	<.001	3	12
LARGE_INTESTINE	EDRF1 →	-0.858	-0.062	<.001	<.001	3	12
OESOPHAGUS	RBM12B →	-1.057	-0.074	.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	ZNF445 →	-0.685	-0.087	<.001	.001	3	12
URINARY_TRACT	S100PBP →	-0.890	-0.083	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007204 vs CCDC150 — URINARY_TRACT

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