Positive regulation of cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytosolic calcium ion concentration pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC3H8, ITGB1, and ABCA3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytosolic calcium ion concentration activity versus ZC3H8 in CNS (Pearson r = -0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ZC3H8 →	-0.424	-0.203	.003	.001	3	6
BONE	ITGB1 →	+1.997	+0.391	.002	.005	2	6
BREAST	ABCA3 →	-1.468	-0.321	<.001	.001	3	5
OESOPHAGUS	LDLRAD3 →	-1.807	-0.266	<.001	.004	3	5
BLOOD_Lymphoma	CELSR3 →	-2.085	-0.386	<.001	.001	3	4
LIVER	SCML2 →	-1.967	-0.308	.007	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007204 vs ZC3H8 — CNS

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