Positive regulation of cytosolic calcium ion concentration

Across TCGA cell cohorts, RNA activity of the Positive regulation of cytosolic calcium ion concentration pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HSP90AA1, ITPR3, and UBE2M, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cytosolic calcium ion concentration activity versus HSP90AA1 in PANCREAS (Pearson r = -0.56).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	HSP90AA1 →	-1.346	-0.328	.005	<.001	3	8
BONE	ITPR3 →	+1.197	+0.371	<.001	.002	3	8
URINARY_TRACT	UBE2M →	-1.366	-0.382	.002	.004	2	9
URINARY_TRACT	CLUH →	-1.442	-0.435	<.001	<.001	3	8
URINARY_TRACT	PFDN2 →	-1.659	-0.363	.005	.009	3	8
BONE	TMEM43 →	+1.210	+0.231	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007204 vs HSP90AA1 — PANCREAS

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