Adenylate cyclase-inhibiting serotonin receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting serotonin receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MTCL1_S1514, MTCL1_S306, and SEMA4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting serotonin receptor signaling pathway activity versus MTCL1_S1514 in COAD (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTCL1_S1514 →	+0.494	+0.095	<.001	.008	3	4
COAD	MTCL1_S306 →	+0.359	+0.066	.003	.003	3	4
LSCC	SEMA4A →	-0.263	-0.250	.002	.001	3	4
LSCC	TRAF3IP3 →	-0.339	-0.231	.009	.008	2	5
LSCC	MS4A1 →	-0.786	-0.331	<.001	.003	3	4
CCRCC	VAV1 →	-0.261	-0.505	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007198 vs MTCL1_S1514 — COAD

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