Adenylate cyclase-inhibiting serotonin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-inhibiting serotonin receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP7, ANTXR1, and PLEKHA3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DUSP7 grouped by Adenylate cyclase-inhibiting serotonin receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DUSP7 →	+0.942	+0.640	<.001	.002	3	5
LIVER	ANTXR1 →	+3.654	+0.242	<.001	.004	3	4
KIDNEY	PLEKHA3 →	+0.662	+0.954	.002	.004	3	4
LUNG_NSCLC_LUAD	KIAA1191 →	+0.480	+0.707	.004	.007	3	4
BREAST	ANXA1 →	+3.715	+0.882	<.001	<.001	3	4
BREAST	ANXA9 →	-2.622	-0.954	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DUSP7 by Adenylate cyclase-inhibiting serotonin receptor signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →