Adenylate cyclase-inhibiting serotonin receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-inhibiting serotonin receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY75-CD302, QSOX1, and MTCP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LY75-CD302 grouped by Adenylate cyclase-inhibiting serotonin receptor signaling pathway-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LY75-CD302 →	+0.446	+2.439	<.001	<.001	3	4
BREAST	QSOX1 →	+0.172	+0.185	.001	.001	3	4
KIDNEY	MTCP1 →	+0.165	+0.303	.009	<.001	3	4
BREAST	ABCA8 →	-0.169	-0.239	<.001	.001	3	4
SKIN	HSPA8 →	+0.394	+0.105	<.001	.003	3	4
BLOOD_Myeloma	MPC1 →	+0.256	+2.209	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LY75-CD302 by Adenylate cyclase-inhibiting serotonin receptor signaling pathway activity — BLOOD_Myeloma

Explore this box plot interactively →