Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTR2, EHBP1L1_S1273, and RELA, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway activity versus ACTR2 in LSCC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACTR2 →	-0.168	-0.998	<.001	<.001	3	6
HNSC	EHBP1L1_S1273 →	-0.457	-0.667	<.001	.002	3	6
PDAC	RELA →	-0.187	-0.679	<.001	<.001	3	5
LSCC	SERPINB9 →	-0.361	-0.733	<.001	<.001	3	5
LSCC	SNX29_S330 →	-0.327	-0.592	.003	.003	3	5
GBM	SNX6 →	-0.202	-0.717	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007197 vs ACTR2 — LSCC

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