Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RARRES1, COX15, and COX7B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RARRES1 grouped by Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RARRES1 →	-2.190	-1.052	.002	.006	3	5
SKIN	COX15 →	+0.292	+0.702	<.001	.002	3	4
PANCREAS	COX7B →	+0.769	+1.313	.004	<.001	3	4
BLOOD_Myeloma	GRINA →	-1.400	-1.669	.004	<.001	3	4
OVARY	MGAT2 →	-0.549	-0.750	.005	.001	3	4
URINARY_TRACT	ACO1 →	-1.407	-0.377	<.001	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RARRES1 by Adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway activity — LIVER

Explore this box plot interactively →