Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CASP4, MYO9B, and AMPD3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway activity versus CASP4 in COAD (Pearson r = -0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CASP4 →	-0.330	-0.770	<.001	<.001	3	7
COAD	MYO9B →	-0.222	-0.792	<.001	<.001	3	7
COAD	AMPD3 →	-0.323	-0.780	.001	<.001	3	6
COAD	ITGAM →	-0.456	-0.444	.001	.003	3	6
GBM	LCP1 →	-0.669	-0.086	.002	<.001	3	6
CCRCC	MICAL1 →	-0.248	-0.603	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007196 vs CASP4 — COAD

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