Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRODH, GRK3, and SEZ6L, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway activity versus PRODH in GBM (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PRODH →	+1.344	+0.977	<.001	<.001	3	1
GBM	GRK3 →	+0.411	+0.666	.004	<.001	3	1
GBM	SEZ6L →	+1.782	+0.648	<.001	.001	3	1
GBM	SOX10 →	+1.146	+0.558	.007	.003	3	1
GBM	SEPTIN3 →	+0.833	+0.710	<.001	<.001	3	1
GBM	RASL10A →	+0.940	+0.832	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007196 vs PRODH — GBM

Explore this scatter interactively →