Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLRG1, STEAP4, and ACTL6A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLRG1 grouped by Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PLRG1 →	+0.632	+2.005	<.001	<.001	3	4
BLOOD_Myeloma	STEAP4 →	-0.256	-0.229	.003	.006	3	3
STOMACH	ACTL6A →	+0.568	+0.337	.001	<.001	3	3
LUNG_NSCLC_LUAD	EIF4G2 →	-0.297	-0.162	.005	.003	2	4
LUNG_SCLC	SPTSSA →	+0.281	+1.463	.006	.006	3	3
LUNG_NSCLC_LUAD	CCDC172 →	+0.237	+0.171	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLRG1 by Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway activity — BONE

Explore this box plot interactively →