Adenylate cyclase-inhibiting dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-inhibiting dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCN4, ACTA2, and COL10A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-inhibiting dopamine receptor signaling pathway activity versus CCN4 in OV (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CCN4 →	+1.048	+0.611	<.001	<.001	3	9
OV	ACTA2 →	+1.392	+0.746	<.001	<.001	3	9
OV	COL10A1 →	+2.688	+1.005	<.001	<.001	3	9
OV	DACT1 →	+1.330	+1.006	<.001	<.001	3	9
OV	LINC01614 →	+1.839	+0.644	<.001	<.001	3	9
OV	COL1A1 →	+2.653	+0.978	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007195 vs CCN4 — OV

Explore this scatter interactively →