Adenylate cyclase-activating dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-activating dopamine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCOR1, RRP1B, and SMC2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-activating dopamine receptor signaling pathway activity versus RCOR1 in LSCC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCOR1 →	+0.368	+0.098	<.001	<.001	3	7
BRCA	RRP1B →	+0.342	+0.048	<.001	<.001	3	6
LSCC	SMC2 →	+0.771	+0.123	<.001	<.001	3	6
PDAC	RPF1 →	+0.373	+0.062	<.001	.002	3	6
GBM	VRK1 →	+0.398	+0.109	<.001	<.001	3	6
LUAD	FNBP4_S965 →	+0.670	+0.119	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007191 vs RCOR1 — LSCC

Explore this scatter interactively →