Adenylate cyclase-activating dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Adenylate cyclase-activating dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSE, RGS16, and HGF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-activating dopamine receptor signaling pathway activity versus DSE in BRCA (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DSE →	+0.640	+0.197	<.001	.001	3	6
HNSC	RGS16 →	+0.760	+0.104	.002	.002	3	6
LSCC	HGF →	+0.764	+0.175	<.001	<.001	3	5
OV	CR1 →	+0.468	+0.087	<.001	.002	3	5
HNSC	RUBCNL →	+0.460	+0.102	<.001	<.001	3	5
BRCA	ATP8B4 →	+0.407	+0.172	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007191 vs DSE — BRCA

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