Adenylate cyclase-activating dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-activating dopamine receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTGER1, DRD3, and RPGR, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTGER1 grouped by Adenylate cyclase-activating dopamine receptor signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PTGER1 →	-0.314	-0.632	<.001	.004	3	9
BREAST	DRD3 →	-0.252	-0.906	.001	.003	3	6
LUNG_NSCLC_LUSC	RPGR →	-0.296	-1.253	.003	.007	3	4
SOFT_TISSUE	TICAM1 →	+0.154	+1.147	<.001	.002	3	4
STOMACH	ITGA8 →	+0.330	+1.300	.002	.006	3	4
BLOOD_Myeloma	TAMALIN →	-0.262	-1.425	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTGER1 by Adenylate cyclase-activating dopamine receptor signaling pathway activity — PANCREAS

Explore this box plot interactively →