Adenylate cyclase-activating dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Adenylate cyclase-activating dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNG2, SYNJ2BP, and GPR89B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adenylate cyclase-activating dopamine receptor signaling pathway activity versus GNG2 in BLOOD_Leukemia (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GNG2 →	+1.864	+0.272	.001	<.001	3	4
BLOOD_Leukemia	SYNJ2BP →	+0.948	+0.266	.005	.002	3	3
LUNG_SCLC	GPR89B →	-0.520	-0.333	.003	.006	3	3
BLOOD_Lymphoma	FNBP1 →	+2.327	+0.301	.002	.005	3	3
BLOOD_Lymphoma	BLM →	-0.907	-0.341	.004	<.001	2	4
BLOOD_Lymphoma	KLRC3 →	-1.941	-0.263	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007191 vs GNG2 — BLOOD_Leukemia

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