Activation of adenylate cyclase activity

Across TCGA patient cohorts, RNA activity of the Activation of adenylate cyclase activity pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HDAC4_S467, REPIN1, and STXBP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of adenylate cyclase activity activity versus HDAC4_S467 in OV (Pearson r = -0.64).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HDAC4_S467 →	-0.836	-0.063	.007	.004	3	5
HNSC	REPIN1 →	-0.435	-0.109	.001	<.001	3	5
GBM	STXBP2 →	+0.414	+0.089	<.001	<.001	3	5
HNSC	CASP4 →	+0.559	+0.088	<.001	<.001	3	5
LSCC	GBF1 →	+0.114	+0.035	.009	.004	3	5
GBM	PLIN3 →	+0.348	+0.081	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007190 vs HDAC4_S467 — OV

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