Activation of adenylate cyclase activity

Across TCGA cell cohorts, RNA activity of the Activation of adenylate cyclase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHB, GCNT1, and OSER1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation of adenylate cyclase activity activity versus PHB in LUNG_SCLC (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PHB →	-0.888	-0.300	.006	.004	3	4
LUNG_SCLC	GCNT1 →	+2.294	+0.212	.005	.001	3	4
STOMACH	OSER1 →	+1.717	+0.404	.004	.003	2	5
OESOPHAGUS	SLC4A3 →	+1.819	+0.270	<.001	<.001	3	4
LIVER	BMPER →	+3.321	+0.168	.001	.003	3	4
LUNG_SCLC	CLCN2 →	-0.826	-0.191	<.001	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007190 vs PHB — LUNG_SCLC

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