Regulation of epidermal growth factor-activated receptor activity

pathway activity — cross-omics
GO:0007176Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of epidermal growth factor-activated receptor activity pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL_Y822, ZFP36L1_S92, and FSTL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCVCL_Y822 →+0.527+0.070<.001<.00135
OVZFP36L1_S92 →+0.735+0.043<.001<.00135
BRCAFSTL1 →+0.441+0.035.006<.00135
OVSHANK3_S1570 →+0.799+0.069.002.00334
HNSCCPSF1 →+0.185+0.081<.001.00134
UCECNFATC4_S334 →+0.465+0.065.001.00134
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration