Negative regulation of epidermal growth factor-activated receptor activity

Across TCGA patient cohorts, RNA activity of the Negative regulation of epidermal growth factor-activated receptor activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are COL5A1, CAMSAP2_S1313, and HSPA4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of epidermal growth factor-activated receptor activity activity versus COL5A1 in BRCA (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	COL5A1 →	+0.491	+0.038	.006	<.001	3	6
OV	CAMSAP2_S1313 →	+0.954	+0.124	<.001	.004	3	5
CCRCC	HSPA4 →	-0.175	-0.044	<.001	<.001	3	5
GBM	SERPINH1 →	+0.585	+0.049	<.001	<.001	3	5
CCRCC	VCL_Y822 →	+0.510	+0.064	<.001	<.001	3	5
OV	ZFP36L1_S92 →	+0.857	+0.077	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007175 vs COL5A1 — BRCA

Explore this scatter interactively →