Signal complex assembly

Across TCGA patient cohorts, RNA activity of the Signal complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCN7A, SLC22A3, and CHTF18, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal complex assembly activity versus SCN7A in LUAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SCN7A →	+1.048	+0.352	<.001	.001	3	4
UCEC	SLC22A3 →	+1.110	+0.162	.002	.005	3	4
CCRCC	CHTF18 →	-0.303	-0.409	.006	.004	3	4
LSCC	NCAPH →	-0.465	-0.275	.009	.005	3	4
LSCC	FANCI →	-0.584	-0.258	<.001	.008	3	4
LSCC	SIAH2 →	-0.483	-0.275	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007172 vs SCN7A — LUAD

Explore this scatter interactively →