Signal complex assembly

Across TCGA cell cohorts, RNA activity of the Signal complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK2, RAD21, and DPF2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal complex assembly activity versus PTK2 in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PTK2 →	+0.878	+1.061	.006	<.001	2	7
BLOOD_Leukemia	RAD21 →	+1.272	+1.282	<.001	<.001	3	6
BONE	DPF2 →	+1.048	+1.628	.004	<.001	3	5
LUNG_SCLC	C8orf76 →	+0.590	+0.542	.001	.001	3	5
KIDNEY	HLA-F →	-1.995	-1.802	.005	<.001	3	5
BLOOD_Leukemia	RASA2 →	+0.867	+1.080	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007172 vs PTK2 — BREAST

Explore this scatter interactively →