Receptor guanylyl cyclase signaling pathway

Across TCGA patient cohorts, RNA activity of the Receptor guanylyl cyclase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTA2, PRELP, and LINC01206, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor guanylyl cyclase signaling pathway activity versus MTA2 in UCEC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTA2 →	-1.160	-0.653	.006	.004	3	3
LUAD	PRELP →	+0.911	+0.118	.005	.006	3	3
LUAD	LINC01206 →	-0.071	-0.128	.007	.007	3	3
PDAC	MIR23B →	+0.895	+0.303	<.001	.004	3	3
UCEC	DAP →	-0.481	-0.534	.001	.002	3	3
UCEC	RABEP2 →	-0.998	-0.647	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007168 vs MTA2 — UCEC

Explore this scatter interactively →