Receptor guanylyl cyclase signaling pathway

Across TCGA cell cohorts, RNA activity of the Receptor guanylyl cyclase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCTEX1D2, VRK3, and ZNF428, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TCTEX1D2 grouped by Receptor guanylyl cyclase signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCTEX1D2 →	+1.486	+1.141	<.001	.001	3	5
BLOOD_Leukemia	VRK3 →	+0.397	+1.007	.002	.001	3	4
BLOOD_Leukemia	ZNF428 →	+0.927	+0.870	<.001	.006	3	4
BLOOD_Leukemia	HMGB1 →	+1.056	+1.205	.001	.001	3	4
BLOOD_Leukemia	SPPL2B →	+0.971	+1.084	.002	.002	3	4
OVARY	POMZP3 →	+0.771	+0.705	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TCTEX1D2 by Receptor guanylyl cyclase signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →