Receptor guanylyl cyclase signaling pathway

Across TCGA cell cohorts, RNA activity of the Receptor guanylyl cyclase signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPR2, UBE2G1, and SMARCD1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor guanylyl cyclase signaling pathway activity versus NPR2 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	NPR2 →	+2.250	+0.611	<.001	.006	3	13
OVARY	UBE2G1 →	-0.660	-0.802	.002	.003	3	7
BONE	SMARCD1 →	-1.166	-1.053	<.001	.007	3	7
BONE	POP1 →	-1.019	-0.943	.003	.006	3	7
LUNG_SCLC	BCL2L12 →	-1.216	-0.867	.004	<.001	3	6
BLOOD_Lymphoma	MMACHC →	-0.962	-1.085	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007168 vs NPR2 — UPPER_AERODIGESTIVE_TRACT

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