Establishment or maintenance of cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MICALL1, RPS6KA4, and BMP1, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of cell polarity activity versus MICALL1 in BONE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MICALL1 →	+1.556	+0.091	<.001	<.001	3	14
BONE	RPS6KA4 →	+1.304	+0.054	<.001	<.001	3	14
BREAST	BMP1 →	+1.572	+0.066	<.001	<.001	3	14
LARGE_INTESTINE	SRGAP2 →	+1.397	+0.053	<.001	<.001	3	13
LARGE_INTESTINE	DLG5 →	+1.312	+0.064	.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	FBXL18 →	+1.107	+0.063	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007163 vs MICALL1 — BONE

Explore this scatter interactively →