Establishment or maintenance of cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR176, PPP1R18, and TNIP1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of cell polarity activity versus GPR176 in LIVER (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GPR176 →	+3.817	+0.368	<.001	.001	3	8
LIVER	PPP1R18 →	+2.409	+0.287	.001	.001	3	7
LIVER	TNIP1 →	+1.937	+0.297	<.001	<.001	3	6
CNS	SMURF2 →	+1.156	+0.153	.002	.008	3	6
LIVER	IFI27L2 →	+2.900	+0.297	<.001	<.001	3	6
LIVER	RAB11FIP4 →	-3.091	-0.297	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007163 vs GPR176 — LIVER

Explore this scatter interactively →