Cell-matrix adhesion

Across TCGA cell cohorts, RNA activity of the Cell-matrix adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFRSF12A, ADAM9, and ANXA2, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell-matrix adhesion activity versus TNFRSF12A in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TNFRSF12A →	+4.298	+0.410	.008	.004	3	10
BONE	ADAM9 →	+2.299	+0.423	<.001	.001	3	10
BONE	ANXA2 →	+2.234	+0.386	.007	.003	2	10
SKIN	ITGB1 →	+1.353	+0.329	<.001	.001	3	9
BONE	CD44 →	+6.252	+0.423	.001	.001	3	8
BONE	EHD2 →	+4.404	+0.415	<.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007160 vs TNFRSF12A — BONE

Explore this scatter interactively →