Neuron cell-cell adhesion

Across TCGA patient cohorts, RNA activity of the Neuron cell-cell adhesion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARL3, DTX3L_S539, and CLEC11A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron cell-cell adhesion activity versus ARL3 in GBM (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ARL3 →	+0.365	+0.139	<.001	<.001	3	7
GBM	DTX3L_S539 →	-0.408	-0.118	<.001	<.001	3	7
OV	CLEC11A →	+0.759	+0.062	<.001	<.001	3	6
GBM	GDI1 →	+0.330	+0.144	<.001	<.001	3	6
GBM	ITSN1 →	+0.304	+0.210	<.001	<.001	3	6
GBM	TLN2 →	+0.183	+0.134	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007158 vs ARL3 — GBM

Explore this scatter interactively →