Neuron cell-cell adhesion

Across TCGA cell cohorts, RNA activity of the Neuron cell-cell adhesion pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA4A, ZNF26, and PTPRQ, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron cell-cell adhesion activity versus SEMA4A in BREAST (Pearson r = 0.73).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SEMA4A →	+2.097	+1.843	.006	<.001	3	4
BLOOD_Leukemia	ZNF26 →	+0.673	+0.817	.002	.003	3	3
BREAST	PTPRQ →	+0.160	+1.670	.006	.001	3	3
BREAST	DECR2 →	+1.297	+2.100	.007	<.001	3	3
BLOOD_Leukemia	FUT4 →	+1.669	+0.809	<.001	.003	3	2
BLOOD_Lymphoma	H2AC13 →	-1.417	-1.302	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007158 vs SEMA4A — BREAST

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