Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

Across TCGA patient cohorts, RNA activity of the Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP6, VEGFC, and CEACAM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules activity versus TNFAIP6 in OV (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TNFAIP6 →	+1.116	+0.566	<.001	<.001	3	4
BRCA	VEGFC →	+0.520	+0.746	.008	.003	3	4
OV	CEACAM4 →	+0.379	+0.681	.004	<.001	3	4
OV	P3H1 →	+0.559	+0.527	.003	.001	3	4
OV	GPR68 →	+0.815	+0.672	.001	<.001	3	4
OV	HLX →	+0.459	+0.926	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007157 vs TNFAIP6 — OV

Explore this scatter interactively →