Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

Across TCGA cell cohorts, RNA activity of the Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EVI5, ZNF841, and AHNAK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EVI5 grouped by Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	EVI5 →	-1.060	-1.797	.003	<.001	3	4
LARGE_INTESTINE	ZNF841 →	-1.072	-0.767	.005	.003	3	4
BLOOD_Leukemia	AHNAK →	-4.126	-1.596	<.001	<.001	3	4
BLOOD_Leukemia	KLF10 →	-1.099	-1.087	.002	<.001	2	5
BLOOD_Leukemia	SKI →	-1.490	-1.140	.004	<.001	3	4
SOFT_TISSUE	RPS27 →	+1.061	+1.255	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EVI5 by Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules activity — URINARY_TRACT

Explore this box plot interactively →